Ganoderic acid D induces synergistic autophagic cell death except for apoptosis in ESCC cells

CS Shao, XH Zhou, XX Zheng, Q Huang - Journal of ethnopharmacology, 2020 - Elsevier
Ethnophamacological relevance Ganoderma lucidum has been used as a medicinal
mushroom for more than 2000 years in China. Ganoderic acid D (GAD) as a representative
active triterpenoid from Ganoderma lucidum is known to possess anticancer activity.
However, the mechanism involved in its anticancer cell process is still largely elusive. Aim of
the study Our study aimed to investigate the anticancer effects of GAD on the esophageal
squamous cell carcinoma (ESCC) cells and the underlying mechanisms at the cell level …
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